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Description
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Biochem/physiol Actions Broad spectrum antibiotic; derivative of oxytetracycline. Broad spectrum inhibitor of matrix metalloproteinases in vivo.
Properties
assay ≥98% (TLC)
storage temp. 2-8°C
Safety
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
WGK Germany 3
References
reference Burggraf, D. et al., Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol. Dis. 25, 506-13, (2007)
Franco, C. et al.,, Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am. J. Pathol. 168, 1697-709, (2006)
Garcia, R.A. et al.,, Molecular interactions between matrilysin and the matrix mettalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol. Pharmacol. 67, 1128-36, (2005)
Lamparter, S. et al., Doxycline and tissue repair in rats. J. Lab. Clin. Med. 139, 295-302, (2002)
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